Ian,
Injuries are part of the game.  Look at Da Bears.  Do you think they were planning on starting a rookie they drafted in the 4th round at QB?  (Go Boilers).  McCallister and Bettis are (were) both injured for the Blitzberg but Willie Parker stepped up.  Weren't the Pats the team that had the beat up secondary last year and still won a title?  Just sayin'
As far as the pick goes, Manning has 14 TD passes, 6 picks and 70% completion percentage.  Manning is throwing one interception for every 40 attempts.
The Colts beat the Pats because the Pats couldn't run the ball against the Colts defense.  34 yards rushing isn't going to get it done.  The Colts defense is tied for first in the league with the Bears at 12.3 points per game.  Pats are allowing 27.5 and are rank 30th.
The Pats have only two games left on their schedule against teams with winning records, the Chiefs @ 5-3 and the Bucs @ 5-3.  The Colts have 5; Bengals @ 7-2, Steelers @ 6-2, Jags @ 5-3, Chargers @ 5-4, Seahawks @ 6-2...
Colts have the tough part of their schedule coming up. I wish the Colts played the Phins and Jets four times in their last 8 games.
Shaun