Unforunately, Dave, someof the spyware installs a program that will continually reset your homepage.
RD do you have windows XP? If so I would suggest saving all your vital info to disks, re-installing XP then right off install service pack 2 from windows update. I would also get Spyware Guard and Spyware Blaster which are both free programs availiable online.
Alternatively, if you want to not format and re-install you can get a prgram called Hijack This! It is a registry editor and when you run it you can eliminate the registry entries for the spyware. Do not abuse this one because you can eliminate some things that will cause your explorer to stop working as well as your installed programs if you are not careful.
All the programs I listed are available at
SpyChecker.